|
KMID : 0882420080750050553
|
|
Korean Journal of Medicine
2008 Volume.75 No. 5 p.553 ~ p.558
|
|
|
Effect of the G-CSF schedule for harvesting peripheral blood progenitor cells from healthy donors
|
|
Lee Sung-Eun
Park Jin-Young
Lee Sung-Won
Choi Ik-Jun
Lee Seok-Ju
Park Chong-Won
|
|
|
Abstract
|
|
|
Background/Aims: Peripheral blood progenitor cells (PBSC) have been used instead of bone marrow cells for allogeneic transplantation. Progenitor cells are mobilized using granulocyte colony stimulating factor (G-CSF). Kinetic studies of G-CSF have shown that the CD34+ cells peak on day 5, although the optimal time for harvesting has not been
established.
Methods: We compared two mobilization schedules using G-CSF. In groups I and II, G-CSF 10 μg/kg/day was
administered subcutaneously for 3 or 4 days, respectively, and leukapheresis was performed the next day.
Results: In groups I and II, a respective mean number of 5.84 × 106 and 10.76 × 106 circulating CD34+ cells per
kilogram of the recipient’s weight was collected by leukapheresis. The yield of the two collections did not differ significantly (p=0.386).
Conclusion: This study suggested that the two mobilization schedules are equally effective. To avoid prolonged
exposure to G-CSF, the day 4 collection schedule is the preferred mobilization strategy.
|
|
|
KEYWORD
|
|
|
Peripheral blood stem cells, Mobilization, Granulocyte colony-stimulating factor, Healthy donor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|